Tobias Hegelund Olsen
I am currently doing a PhD in Immunoinformatics in the Oxford Protein Informatics Group (OPIG), University of Oxford. I am funded via the EPSRC Sustainable Approaches to Biomedical Science Centre for Doctoral Training: Responsible and Reproducible Research (SABS:R3) program.
My research focuses on designing and building in silico tools for engineering immunological proteins (i.e. antibodies, T-Cell Receptors, MHCs, etc.). For this, I make use of deep learning and other data science approaches. I have experience working with humanization, antibody paratope prediction, TCR:p:MHC structure prediction and affinity prediction. I have collated, processed and worked with both structural data as well as billions of amino acid sequences. Additionally, I have worked on predicting useful bioactivities for peptides. My current work focuses on improving the developability of therapeutic antibodies by utilising large antibody sequence datasets and language models.